Wilson (2-0) went 5 1-3 innings, allowing seven hits and three runs. He walked two and struck out a season-high nine.
Ernesto Frieri pitched the ninth for his third save in three chances.
The Angels would not let Mariners' starter Aaron Harang (0-3) settle in. They scored in each of the first three innings for a 5-0 lead, chasing Harang before the fourth.
Peter Bourjos opened the game with a single followed by Mike Trout's hit. Bourjos took third and scored on Albert Pujols' sacrifice fly to center.
Conger connected in the second inning, his first home run, and Trumbo hit his third in the third.
The scoring outburst ended the Mariners' 18-0 scoring run over the Angels that included Thursday's 6-0 victory and a 12-0 decision on the final game of 2012.
The Mariners still have not won consecutive games since the season's first two games. They were 1-for-12 with runners in scoring position and left 15 runners stranded.
Kyle Seager singled in the fourth to give him a career-high 15-game hit streak, longest in the majors this season. He is batting .393 during the streak with seven doubles, three home runs and 11 RBI.
The Mariners' had two prime opportunities to unravel Wilson, loading the bases in both the fourth and fifth with less than two outs. They managed just one run.
Seager and Kendrys Morales opened the fourth with singles and Michael Morse earned a nine-pitch walk to load the bases with no outs. After Justin Smoak struck out, Kelly Shoppach was hit by a pitch, forcing in a run. He has been hit 55 times in his career, the second time with the bases loaded.
Wilson then struck out Robert Andino and Endy Chavez.
A pair of singles by Brendan Ryan and Jason Bay in the fifth was followed by one-out walk to Morales, loading up more trouble for Wilson. But he got Morse on an infield popup and struck out Smoak.
The Mariners finally scored a pair of runs in the sixth. Shoppach singled and Andino doubled. Chavez hit a sac-fly to center, scoring Shoppach and ending Wilson's evening.
Ryan then greeted reliever Sean Burnett with a first-pitch squeeze bunt, scoring Andino to make it 5-3.
The Angels scored in the seventh on Pujols' second sac-fly.
The Mariners had a final two-out chance in the eighth but Smoak was thrown out at the plate on pinch-hitter Dustin Ackley's infield single.
Notes: OF Michael Saunders (right AC joint) joined Triple-A Tacoma in Las Vegas Friday for a rehab assignment. "The earliest (return) would be Monday," Mariners manager Eric Wedge said. "We'll see how he feels." Mariners' prized prospect, LHP Danny Hultzen, has been diagnosed with a strained left rotator cuff and tendinitis. He will rest and rehab for two weeks. Jason Bay, hitting .220, started as the leadoff hitter for the first time in his 10-year career. ... With Erick Aybar and Alberto Callaspo on the DL, Angels manager Mike Scioscia said, "what's missing is the balance they give you. They're both switch-hitters. We didn't match up as well (Thursday) as we could have."