The Wildcats (15-0, 2-0 Pacific-12) are off to their best start since 1931-32, when the team set a school record with 16 wins to open the season.
T.J. McConnell added six assists, five rebounds and four steals.
C.J. Wilcox led Washington (9-6, 1-1) with 20 points. Perris Blackwell had 12 points and 12 rebounds. Freshman Nigel Williams-Goss chipped in 9 points and 4 assists.
Arizona trailed by two at halftime but pulled away as the Huskies shot 10 of 33 in the second half, missing all seven 3-point attempts.