The Aggies (18-8, 7-3 Western Athletic Conference) shot 57.6 percent from the field, with Nephawe going 10 of 14. DK Eldridge scored 15 points, K.C. Ross-Miller had 13 and Renaldo Dixon contributed 11.
Seattle U (11-11, 3-6) shot 43.5 percent and was 6 of 16 from beyond the arc. Isiah Umipig, a Federal Way High School product, led the Redhawks with 24 points and D'Vonne Pickett Jr. had 18.
New Mexico State made three late shots in the first half to grab a 45-36 halftime advantage. They pulled ahead in the second with a 20-6 surge as a Nephawe jumper made it 65-47 at the 12:40 mark.
Seattle cut their deficit to nine with 6:23 remaining, but the Aggies responded with a 10-0 run to put the game away.