Police say the suspect was driving south in the northbound lanes of I-5 when the black truck collided with a Ford Edge near 145th street.
The Ford Edge was totaled and left a 50-year-old man injured. The man was transported by paramedics to Harborview Hospital for treatment of minor injuries. His current condition is unknown, and the other passengers were uninjured.
The driver of the truck sustained no injuries in the collision.
Police say they arrested the wrong-way driver for investigation of driving under the influence.