Seattle Fire Department's Kyle Moore says the woman was unconscious when firefighters rescued her from a second-floor bedroom. Firefighters attempted to perform CPR on the woman but could not revive her. She was pronounced dead at the scene.
The fire broke out around 1 a.m. in the 3700 Block of Cascadia Avenue South, near Stan Sayres Memorial Park.
Firefighters were forced to evacuate the home when flames became too dangerous. Moore says the blaze completely destroyed the two-story home, causing an estimated $2 million in damages.
The near 3600-foot home was built in 1905, and was the first to be built on the block. Home to the same family for over 40 years, it once had a ballroom on the third floor.
The woman who owns the home has not returned and was away with family when the fire started.
The deceased rented a room in the home and had physical challenges, officials said.
Investigators have not yet determined what caused the fire.