Sea-Tac Airport was virtually empty on Tuesday night, but that won't be the case on Wednesday, when 91,000 passengers are expected to pass through. Elsewhere, travelers going through Los Angeles could be impacted by an airport worker demonstration.
The good news is that the weather appears to be cooperating.
"If there were to be storm in Chicago or in the northeast, you could count on mass chaos. But that does not look like that is going to be the case at all," said Genevieve Brown of ABC News.
Meanwhile, warning are going out to local ferry travelers to expect long lines. Transportation authorities say the longest lines are expected on westbound ferries Wednesday afternoon and evening and eastbound ferries on Friday morning.
Those thinking of driving around it all should think again. Local freeways will be jammed on Wednesday from before dawn until after sunset. The Washington Department of Transportation says Wednesday will be one of the busiest travel days on I-90 over Snoqualmie Pass and a Highway 2 over Stevens Pass.
Travelers looking to avoid the stress by hopping on a train will also be disappointed. Northline Sounder service between Seattle and Everett is cancelled all Wednesday because of mudslides and there's no service on Thanksgiving day.
Most airline travelers are expected to return on Sunday, which means another busy day at Sea-Tac and other airports nationwide.