The shooting happened just before 7:30 p.m. in the 7500 block of 15th Avenue NE.
Officers responded after receiving 911 calls from neighbors who heard shots fired. When police arrived they found a man in his early 40s sitting in the driver's seat of a maroon Subaru in the middle of the street. He had been shot several times.
Medics transported the victim to Harborview Medical Center, where he later died from his injuries.
According to police, the suspect pulled up next to the victim's car and for unknown reasons opened fire at him, hitting him several times.
The suspect was last seen leaving the area driving a smaller silver or gray BMW. He is described as a white male in his late 20s to 30s with dark hair.
Homicide and CSI detectives are continuing to investigate this incident and ask anyone with any information to call 911 or the Seattle Police Homicide Tip Line at (206) 233-5000. Anonymous tips are welcome.