The crash happened just before 10 a.m. along Beverly-Burke Road SW and County Road One. The crash caused the SUV the four people were riding in to fall into an irrigation canal.
The identities of the four people killed have not been released.
The driver of the other car suffered minor injuries.
The adults died at the scene. The children were being given CPR at the scene and were then transported to an area hospital where they died.
Investigators are trying to find an exact cause of the crash.