"For the third time in a week, Seattle has suffered a devastating loss of life as result of guns," Seattle Mayor Ed Murray said in a statement.
Police responded to South Main Street and 12th Avenue and found a man in his 20s dead.
The suspect or suspects fled the scene, and police say no witnesses are cooperating.
"There have been quite a few incidents in this area. And we are definitely watching it. The officers are very aware and there's a lot of patrols that go on in the area, especially on weekends with nice weather," Detective Drew Fowler said.
Along with the victim, several businesses and vehicles were also hit by gunfire. Officers recovered at least 30 bullet casings from the scene.
"Once again, it is members of our East African community who feel the pain of this violence most directly," Mayor Murray said. "And once again, we as a city together mourn the loss of one of our young men taken too soon."
Anyone with information is asked to call either 911 or the Seattle homicide tip line at 206-233-5000.