Troopers and medics responded the scene at about 1:10 p.m. Friday after receiving a report of a serious crash.
One of the vehicles rolled over in the collision. There were reports of multiple people injured.
All northbound traffic was diverted off the freeway at the scene for an hour after the accident. A six-mile backup had formed in both directions within a half-hour after the crash.
All lanes had reopened by 2:20 p.m.
The circumstances leading to the crash remain under investigation.