Sgt. Bob Bohl said the two men kicked in a door at the home in the 1300 block of South 251st Street and demanded money from the man and woman who were inside.
The 53-year-old homeowner got into a fight with the intruders and was pistol whipped and shot in the abdomen, Bohl said. He was taken to Harborview Medical Center in Seattle and was expected to survive.
The intruders left after the shooting and remain at large. The woman who was in the home was not hurt.
Investigators are still trying to determine if the home was targeted.
"The victim's house is kind of tucked away a little bit," Bohl said. "Somebody would really have to know the area a little bit to know the house is back there."
Bohl said one of the intruders is white, in his late 20s, with a shaved head or close-cropped hair with a red scruffy and unshaven face. No description of the second intruder was available.
Anyone with information is asked to call Des Moines police at 206-878-3301.