Renton Fire Department Battalion Chief John Lecoq said firefighters got the woman out through a window just after they arrived.
The woman, who is in her 60s, was taken to a hospital to be treated for smoke inhalation.
Two other people who were in the home when the fire broke out about 4:40 a.m. were able to get out on their own, Lecoq said.
It took firefighters about 30 minutes to extinguish the fire at the home in the 16000 block of 132nd Place Southeast.
The cause of the fire is under investigation.