Police and medics responded to the scene, Aurora Avenue North at North 125th Street, at about 12:10 a.m. Friday after receiving reports of a serious crash.
Arriving at the scene, they found that a passenger car had collided with a Jeep. Four people were injured, one of them seriously. All were taken to the hospital.
The circumstances leading to the crash were not immediately available.
Aurora Avenue North was shut down for several hours during the cleanup and investigation.