Police say the accident occurred just after 4:30 p.m. at 12th and Spruce as the officers were responding to a deputy-involved shooting in SoDo.
A male and female officer, as well as two other men, were taken to Harborview Medical Center. All four were listed in stable condition Monday evening.
There is no word yet what led up to the crash.
Seattle police say 12th Avenue will be blocked around the crash site until approximately 8 p.m.