The incident unfolded at about 1 a.m. in the 16700 block of 31st Avenue South, just east of International Boulevard. Police responded after receiving a report of multiple shots fired.
After the shooting and crash, one of the wounded men fled the scene to a nearby bank where he collapsed with at least one gunshot wound. He was taken to Harborview Medical Center with life-threatening injuries.
Another person from the same bullet-riddled car checked himself into into nearby Highline Medical Center with at least one gunshot wound, police said.
Detectives are looking for the shooters and continue to investigate at the scene where the victims' car crashed into several parked cars in an apartment parking lot.
It is not yet known if the shooting was a random act or the people in the car were specifically targeted, police said.