The two men were arrested Saturday morning and booked into Pierce County jail on suspicion of murder, Tacoma Police public information officer Loretta Cool said.
Kevin Young was shot and killed inside a room at the King Oscar Motel.
Cool says the 41-year-old man's girlfriend called 911 just before 6 a.m. on Thursday to report Young had been shot. He was pronounced dead at the hospital.
No motivation for the shooting was provided.