State troopers responded to the scene, at Marina Drive and Tyee Drive in Point Roberts, at about 5:40 p.m. after receiving a report of a serious crash.
The driver was pronounced dead at the scene. The name, age and hometown of the driver were withheld pending notification of next of kin.
A preliminary investigation found that the driver was heading south on Tyee Drive in a 2002 Chevy Avalanche when the pickup veered off the roadway at a curve.
The driver swerved to the left, then back to the right, then veered off the road, crashing through a fence before slamming into four boats and a motorhome at a marina.
No one else was reported to be hurt in the crash.
It is unknown whether drugs or alcohol were a factor in the deadly accident.