Eyewitnesses said it sounded like "a bomb going off" when the bus tire blew out near the intersection of 12th Avenue South and S. Jackson Street at about 9 a.m. Friday.
"I mean really like a bomb. Boom! Amazing, the first time in my life I heard a flat tire like that," a chef from a nearby restaurant said.
Four people walking on the sidewalk nearby were hit by the flying debris from the tire.
Ambulances responded to the scene and medics treated a woman, two boys and a girl for abrasions. They were taken to a hospital to make sure they didn't have more serious injuries.
A long gash was visible in the side of the tire after the incident.