A 911 call led investigators to the Greenwood Apartments, in the 5300 block of San Francisco Ave. SW, at around 9:45 p.m.
They arrived to find a 32-year-old man with a gunshot wound to the chest. Medics could not revive the man and he was pronounced dead at the scene.
The victim's 33-year-old roommate was home asleep at the time of the shooting and told police he was awakened by his roommate yelling for him, then heard a gunshot.
The roommate came out, found the man shot, and dragged him out to the front door telling neighbors to call 911.
Police say the roommate said he did not see the shooting and does not know what happened.
A witness reported seeing another man talking to the victim prior to the shooting, but didn't get a good description.
A large quantity of drugs was found in the apartment, police said, adding it's possible drug trafficking played a role in the murder.
The name of the man who was killed has not been released.