The Billboard Hot 100 has been tracking songs since August 1958.
"Can't Hold Us," a song Mackmore and Lewis performed with Seattleite Ray Dalton on "Saturday Night Live," moved from No. 2 to the top spot this week. Their earlier No. 1, "Thrift Shop," was atop the chart for six weeks, although not consecutively.
"Thrift Shop" dropped from No. 4 to No. 6 on the Hot 100 chart. Lady Gaga in 2009 was the last person to send her first two charted Hot 100 singles to the top spot (with "Just Dance" and "Poker Face").
The last Seattle artist to reach that spot was Sir Mix-a-Lot with "Baby Got Back" in 1992. Macklemore has previously said he wanted Mix-a-Lot to be in the video for "Thrift Shop," but he didn't hear back.
The only other Seattle artists to reach No. 1 on the Billboard Hot 100 list are Heart ("These Dreams" in 1986 and "Alone" in 1987), Paul Revere and the Raiders ("Indian Reservation," 1971) and Olympia-based group The Fleetwoods, who recorded in Seattle ("Come Softly To Me" and "Mr. Blue," 1959).
Some of Seattle's best-known bands - Nirvana, Pearl Jam, Soundgarden, Alice in Chains, The Presidents of the United States of America - never had a single reach the top spot. Even Jimi Hendrix didn't, though he had a style not geared toward producing pop radio hits.
"Thrift Shop" is the most successful track off "The Heist," the first studio album from Macklemore and Lewis, which debuted at No. 1 on iTunes when it was released last October. The album has reached the second spot on the Billboard 200 chart, which tracks top-selling albums across all genres. And the pair have done it all without a record contract.
Macklemore, also known as Ben Haggerty, is a Seattle native who attended Garfield and Nathan Hale high schools. The 29-year-old has become popular with fans through annual appreciation parties, his openness about his battles with drug addiction and alcoholism, and his song "Same Love" with Lewis and vocalist Mary Lambert, which supports same-sex couples.
On Mariners opening day in 2011, Macklemore and Lewis performed "My Oh My" at Safeco Field - their tribute to beloved Mariners broadcaster Dave Niehaus that went viral shortly after his death in November 2010.
Videos for "Thrift Shop," "Same Love," and "My Oh My" have received more than 334 million views on YouTube.