Emergency personnel responded to the scene, at the intersection of Cooper Point Road and Capital Mall Drive SW, at about 6:15 a.m. after receiving a report of a serious crash involving a car and pedestrian.
The jogger died at the scene.
A preliminary investigation found that the car was entering the busy intersection when it struck a man who was jogging through at the same time. The driver stayed at the scene after the collision.
Police are interviewing the driver and witnesses. It was not immediately clear whether the car or the jogger had the right-of-way at the time of the crash.
The intersection, which is normally very busy, will be closed for at least six hours as the investigation proceeds, police said.
The identity of the jogger was not immediately available.