Police and medics responded to the scene, at South 19th Street and South I Street, at about 1:30 p.m. after receiving a report of a serious accident.
Three people were found to be injured. All were taken to area hospitals.
In the aftermath of the crash, an SUV ended up on its side against a parked car. Two other vehicles were also involved. It was not immediately clear what circumstances led to the crash.
South 19th Street is currently closed between J Street and Yakima Street as police investigate the accident.
This is a developing news story. More information will be posted as it becomes available.